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J Virology 1983, 46:196–203.PubMed Authors’ contributions JQ, XQ, YS and FD devised, carried out and NADPH-cytochrome-c2 reductase analyzed the experiments described in this report. LM conceived the project and drafted the manuscript. All authors read and approved the final manuscript.”
“Background Mycobacterium Caspase Inhibitor VI tuberculosis is a major global pathogen. In 2007, approximately 1.7 million
deaths were caused by tuberculosis (TB) and an estimated 9.3 million people acquired the infection . Patients can usually be cured through a six month course of a multiple drug regimen . The efficacy of chemotherapy has however been compromised by the appearance of multi- and extensively drug resistant strains [3, 4]. The search for potential novel drug targets and the subsequent development of new antibiotics is therefore urgent. Ideal candidates would be mycobacterial-specific and include pathways involved in the biosynthesis of the unusual cell envelope [5, 6]; the target of some existing antibiotics, including isoniazid, ethionamide, ethambutol and pyrazinamide . Inositol is a polyol that is not synthesized in most bacterial species. However, in the mycobacteria, inositol is found in lipoarabinomannan (LAM), a lipoglycan that is present in high levels in the cell envelope. LAM is composed of a mannan backbone with branched arabinosyl chains. It is anchored in the cell envelope by means of a phosphatidylinositol (PI) moiety. Other lipoglycans found in the cell envelope include lipomannan (LM) and PI mannosides (PIMs).