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“OBJECTIVE: Open lumbar spinal surgery in overweight or obese patients has been associated with increased risk of perioperative complications. The impact of minimally invasive spinal (MIS) surgery on the incidence of perioperative adverse events in overweight or obese patients, however, has not been well evaluated.

METHODS: A retrospective review of consecutive patients undergoing lumbar MIS surgery from January 2006

to April 2007 was performed. Of the 77 patients identified, 56 had a body mass index (BMI) of 25.0 kg/m(2) or greater.

RESULTS: Of the 56 patients with a BMI of 25 kg/m(2) or greater, 32 (57.1%) were men; the mean age was 54.1 years. The mean BMI was 31.0 kg/m(2) (range, 25.1-43.8 kg/m(2)). Using a broad definition of an adverse event, eight (14.3%) complications were identified. in the discectomy/laminotomy subgroup (31 patients), two (6.5%) adverse events were noted. In the fusion subgroup (25 learn more patients), six (24%) adverse events were noted, most of which were minor. Of the 21 patients with a BMI less than 25 kg/m(2), eight (38.1%) were men, and the

mean age was 43.7 years. The mean BMI was 22.5 kg/m(2) (range, 16.8-24.6 kg/m(2)). Three (14.3%) complications were noted overall. In the discectomy/laminotomy subgroup (17 patients), two (11.8%) adverse events occurred. One (25%) complication developed in the four patients making up the fusion subgroup. There was no statistically significant difference in complication rates between groups. Logistic regression also found no statistically significant relationship between BMI and perioperative complications.

CONCLUSION: see more There does not appear Elafibranor ic50 to be an increased risk of developing perioperative complications in overweight or obese patients undergoing MIS surgery, which may reflect a potential benefit of the MIS approach.”
“Objectives: Risk factors for atherosclerosis have limited ability to identify persons at high risk of coronary heart disease. Assessment of subclinical atherosclerosis in peripheral arteries might improve this limitation.

We studied the relationship between atherosclerotic plaques in peripheral arteries, coronary plaques, and coronary death.

Methods: Predefined segments from the left anterior descending coronary artery, the right coronary artery, bilateral carotid, and superficial femoral arteries (SFA) were obtained from 100 autopsies (20-82 years, 30 females, 27 coronary deaths). Based on microscopic examination of 4756 sections, the extension of atherosclerosis (plaque burden) and the largest plaque area in each segment were quantified.

Results: Plaque burden in all arteries increased with age and was larger in coronary death (P <.05). SFA plaques occurred later than coronary and carotid plaques. When SFA plaque had developed, coronary plaque was also present. SFA plaque (odds ratio, 95% confidence interval: 7.07 [2.40-20.