Leydig cells were normal. Initial effects were observed in Sertoli cells at 60 days of treatment. Spermatocytes and spermatids were affected after 120-240 days of treatment. A significant decline in sperm count and viability, total inhibition of sperm motility, increased numbers of sperm abnormalities, normal serum testosterone levels
and 100% sterility were evident after 60 days of treatment. All the altered parameters, including percent fertility, were restored to control level 120 days after treatment withdrawal. It is concluded that the MSF is safe for long-term treatment and the mechanism of contraception is shown by its effect on spermatid differentiation in the testis, possibly mediated by the Sertoli cell factors.”
“Difficulties selleck kinase inhibitor with visual-spatial learning are frequently observed and often considered to be the hallmark of neurocognitive impairment HKI272 in neurofibromatosis type 1. The computerized Arena Maze is a virtual environment task that has been developed as a human paradigm to the Morris Water Maze, which is used to evaluate spatial learning in animal models. The authors evaluated this task as a measure of spatial learning in children
with neurofibromatosis type 1 compared with their unaffected siblings. Affected children were able to learn the task and navigate the virtual environment; however, they performed more poorly on standard measures of spatial learning and spatial working memory
than their siblings. The group with neurofibromatosis type 1 demonstrated decreased proficiency in earlier target trials and had more difficulty in remembering target location. This study demonstrates the potential utility of a novel virtual task to assess spatial learning deficits in children with neurofibromatosis type 1.”
“Study Design. Case report of 2 patients with traumatic L4-L5 spondyloptosis.
Objective. To report the diagnosis and treatment of the traumatic L4-L5 spondyloptosis.
Summary of Background Data. Traumatic L4-L5 spondylolisthesis is even rarer than traumatic L5-S1 spondylolisthesis. No case of traumatic L4-L5 spondyloptosis (anterolisthesis CB-839 mechanism of action of Grade V) has been reported. The injury mechanism and surgery management merit more studies.
Methods. Through the posterior approach, both of the 2 patients underwent the decompression and reduction with pedicle screws. One had the posterolateral fusion and the interbody fusion from L4-L5 whereas the other had the posterolateral fusion from L4-S1.
Results. Complete reduction and fusion were achieved. The neurologic symptoms improved after the surgery. At follow-ups of 1 year and 6.5 years, there was no further slippage of the vertebrae. They were satisfied with the treatment outcomes.
Conclusion. Posterior decompression, reduction, internal fixation, and fusion is effective and dependable for traumatic L4-L5 spondyloptosis.