Inventing new inorganic scintillating materials with high carrier mobility can lead to a class of proportional inorganic scintillators. Results agree qualitatively with experimental results for the dependence of light yield on the incident energy. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3607247]“
“BACKGROUND: AZD6094 Chronic rejection (CR) is the main reason for the limited survival rates among lung transplant (LT) recipients. There remains no effective treatment for CR. The aim of this study was to identify
new molecular mechanisms involved in CR by using DNA microarray analysis.
METHODS: We performed 10 left LTs using the microsurgical cuff technique in inbred Sprague-Dawley rats. Lung isograft
samples were obtained 3 months after surgery. We analyzed histologic, apoptotic and gene expression changes by DNA microarray and quantitative PCR analysis.
RESULTS: Histologic analyses confirmed signs of CR in all lungs and positive labeling for apoptotic and anti-apoptotic markers. A total of 702 genes were regulated in the CR lungs: 317 genes were upregulated and 385 were downregulated. Significant changes for about 30 biologic processes, including regulation of the cytoskeleton, and 15 signaling pathways, such as adherens junctions, were observed. We found Semaxanib Protein Tyrosine Kinase inhibitor significantly increased mRNA expression of the Cldn5, Epas1, Tgfb1, CHIR98014 nmr Vegf,
Selp1, Hsp27 and Igf1 genes.
CONCLUSIONS: This is the first experimental study performed in an orthotopic model of LT using DNA microarray analysis. The individual genes, biologic process and pathways identified may represent novel targets that could be manipulated and contribute to the development of treatments capable of providing protection from CR. J Heart Lung Transplant 2012;31:213-21 (C) 2012 International Society for Heart and Lung Transplantation. All rights reserved.”
“Background: Community-acquired pneumonia (CAP) is a major cause of morbidity in industrialized countries and morbidity/mortality in developing countries. In China, comprehensive studies of the etiology of CAP in children aged between 2 months and 14 years who are serious enough to require hospitalization are lacking. Previous studies have been limited in child age range, focused on fatal cases, and/or limited in etiologies sought. An understanding of the etiologies is needed for development of best prevention and management practices.
Objective: The aim of this study was to prospectively determine during a 12-month period the etiology of CAP in hospitalized children in a center in Northwest China.
Design/Methods: A prospective 12-month study (2004-2005) of CAP cases in children who were 2 months to 14 years of age admitted to the Second Hospital of Lanzhou University, China.