In summary, our results indicated that GA showed a dual inhibitory role on JNK3 activation and exerted strong neuroprotection in vivo and in vitro, which provides a new possible approach for stroke therapy. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Background: Hybrid technique

with open surgical supra-aortic extra-anatomical bypasses (to provide a suitable proximal landing zone) and simultaneous or staged thoracic endovascular stent grafting is less invasive than open surgery in the treatment of complex aortic arch pathology. The aim of this study is to report our hybrid experience.

Methods: Retrospective review of prospectively collected computerized database. All patients had regular clinical selleck kinase inhibitor and radiological computed tomography follow-up.

Results: click here Sixteen patients (13 males and 3 females) with mean age of 64.8 (range 51-79) were treated with hybrid techniques between May 2005 and September 2007. There were nine elective, two urgent (within 2 weeks of presentation), and five emergency cases. Thirteen patients had arch or proximal descending thoracic aortic aneurysms,

and six patients had aortic dissections. All extra-anatomical bypasses were performed simultaneously with stent grafts, with mean operating time of 331.2 (range 195-540) Minutes. Eight patients had right the to left carotid-carotid cross-over graft, live had bifurcating grafts from ascending aorta to innominate

and left carotid artery, two had left carotid to left subclavian artery, and one had left carotid to aberrant right subclavian bypass graft. All patients had Cook Zenith thoracic stent grafts. Deployment success was 100%, with no endoleak on completion angiogram. There was no mortality. Three patients had postoperative nondebilitating stroke and no paraplegia. The mean follow-up was 14 (range 1-27) months. One reintervention was required, and two patients had type TT endoleak treated conservatively.

Conclusion: Supra-aortic hybrid procedures in treating aortic arch pathology are safe and effective, and early- to midterm results are encouraging.”
“Spinal cord injury (SCI) in mammals leads to a robust inflammatory response followed by the formation of a glial and connective tissue scar that comprises a barrier to axonal regeneration. The inbred MRL/MpJ mouse strain exhibits reduced inflammation after peripheral injury and shows true regeneration without tissue scar formation following an ear punch wound. We hypothesized that following SCI, the unique genetic wound healing traits of this strain would result in reduced glial and connective tissue scar formation, increased axonal growth, and improved functional recovery.