Cancer Genet Cytogenet 2004, 148:
80–84.PubMedCrossRef 16. Kijima T, Maulik G, Ma PC, Tibaldi EV, Turner RE, Rollins B, Sattler M, Johnson BE, Salgia R: Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells. Cancer Res 2002, (62) : 6304–6311.PubMed 17. Xiang ZL, Zeng ZC, Tang ZY, Fan J, Zhuang PY, Liang Y, Tan YS, He J: Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival. BMC Cancer 2009, 9: 176.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions NL and SQC conceived, www.selleckchem.com/products/AZD0530.html coordinated and designed the study and contributed to the acquisition, analysis and interpretation of data and drafted the manuscript. WXG performed the experiments and were involved in drafting the article. JS and
JX selected archived samples and participated in the study design and interpretation this website of the results. HSH participated in sample collection and data acquisition. All authors have read and approved the final manuscript.”
“Introduction Acute lymphocytic leukemia (ALL) is the most common malignancy diagnosed in children, and it accounts for approximately one-third of all pediatric cancers. Although contemporary treatments cure more than 80% of
children with ALL, some patients require intensive treatment and many patients still develop serious acute and late complications because of the side effects of the treatments . Therefore, new treatment strategies are needed to improve not only the cure rate but also the quality of life of these children . Glycogen synthase kinase-3 Etofibrate (GSK-3) is a serine/threonine protein kinase, whose activity is inhibited by a variety of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion [3–5]. Two homologous mammalian GSK-3 isoforms are encoded by different genes, GSK-3α and GSK-3β. Recently, GSK-3 has been recognized as a key component of a diverse range of cellular functions essential for survival . Fibroblasts from GSK-3β-deficient embryos were sensitized to apoptosis and showed reduced nuclear factor-κB (NF-κB) function . Furthermore, it has been shown that GSK-3β is a prosurvival factor in pancreatic tumor cells, partly through its ability to regulate the NF-κB pathway . These findings suggest a role for GSK-3β (but not GSK-3α) in the regulation of NF-κB activation. mTOR inhibitor Recent experimental evidence has suggested that inhibition of GSK-3β abrogates NF-κB binding to its target gene promoters through an epigenetic mechanism and enhances apoptosis in chronic lymphocytic leukemia (CLL) B cells ex vivo .