5 patients were in situ carcinoma (TiS), 13 were T1-stage cancer, and 6 had recurrent esophageal cancer. PDT with different outputs (630 nm wavelength, 260–2000 mW of power, energy dose of 120–400 J/cm) according to the patient’s state was initiated. Therapy response, recurrence rate, survival outcome, and complication of the patients were evaluated. The follow-up period ranged from 2 to 95 months. Results: 21 cases were treated with Photofirn, 3 with photogem, 2 with Photodin, 4 with radachlorin and 2 with ALA. Sensitizer types showed no difference

in complete response (CR) rate or complications. The CR rate was 62.5% (15 of 24) in patients who received PDT. The CR rate was statistically higher (p = 0.027) for patients who had Tis/T1 lesion (14 of 18; 77%) learn more than for those with recurrence (1 of 6; 16%). There was one patient that had recurrence

12 months after PS-341 cost PDT. The survival time was statistically higher (P = 0.003) for patients who had Tis/T1 lesion (86 months) than for those with recurrent tumors (32 months). We experienced six cases of esophageal stenosis (25%) that required dilatation and one case of esophageal perforation (4%) that required operation after PDT. Conclusion: The role of PDT in recurred esophageal cancer is limited, but PDT might be an effective regimen for early esophageal cancer, with overall favorable survival time, and low recurrence rates. Key Word(s): 1. Photodynamic therapy; 2. Esophageal cancer; Presenting Author: ENQIANG LINGHU Additional Authors: ZHICHU QIN Corresponding Author: ENQIANG LINGHU click here Affiliations: Department of Gastroenterology and Hepatology, the

Chinese PLA General Hospitall; Department of Gastroenterology and Hepatology, the PLA General Hospital Objective: This animal study was performed to explore the feasibility and safety of endoscopic transesophageal biopsy using submucosal tunneling technology and novel homemade instruments in the posterior mediastinum. Methods: In 3 survival pigs, a mid-esophageal mucosal incision was performed and a 10-cm submucosal tunnel was developed with blunt dissection. The endoscope attached to homemade decompression tube was passed through the muscular layers into the posterior mediastinal space. The mediastinal compartment, lung, thoracic duct, vagus nerves, and exterior surface of the esophagus were identified. Mediastinal living tissue as lymph node biopsy was accomplished. During two survival weeks, blood test and temperature monitoring and chest radiograph and endoscopic examination were performed. Results: The procedure was performed successfully in all pigs. Mediastinal structures could be identified without difficulty though the transesophageal tunneling approach. Living tissue as lymph node and pleural biopsy under direct visualization was feasible. One pig died after operation due to an unexplained pneumothorax.