We were interested to learn whether 1 x 30 mg of alemtuzumab is as effective as 2 x 20 mg. Patients of the initial study group (group A) received 20 mg alemtuzumab on days 0 and 2, and tac monotherapy from day 2 on. This group acted as control group

for the new arm (group C), where patients were given only 1 x 30 mg alemtuzumab on day 0 followed by Tac monotherapy from day 2 on with the same target levels as in the control group. Frequency of rejection at 6 months was 15% in the control group compared to 6% in the study group and 20% at 12 months in group A versus 6% in group C (P = 0.034). Time to rejection was 4.9 months in group A and 0.8 in group C. One-year patient survival was 98.5% in both groups, graft survival 96.9% in group A, and 98.5% in group C. Safety profile was similar in both groups apart from more viral and bacterial infections in group C. Single shot alemtuzumab induction of 30 mg is as effective as 2 x 20 mg in cadaveric renal PLX4032 in vitro GSK923295 in vivo transplantation.”
“We

report the magnetic field and temperature dependences of ac electrical transport in La0.5Ca0.5 Mn0.96Ni0.04O3 as a function of frequency. The ac magnetoresistance shows an anomalous behavior as a function of field: it is negative and exhibits a bell shaped curve about the origin (H = 0 T) at f = 0.1 MHz, but it transforms into a valley at the origin (accompanied by a positive peak on either side of the origin) for f >= 3 MHz at T = 125 K. With increasing frequency, the depth of the valley increases and the position of the peak shifts toward higher field. However, the magnetoreactance is negative and exhibits only a single peak at the origin for all temperatures and frequencies. At T = 125 K and f = 5 MHz, a magnetoresistance of vertical

selleck bar 80% and a magnetoreactance of similar to 90% were found for H = 2 T. These results are very different from those for La0.7Sr0.3MnO3, and we discuss the possible origins of the observed anomalous ac magnetotransport in this compound. (c) 2011 American Institute of Physics. [doi: 10.1063/1.3556758]“
“Purpose: To investigate the potential of spectral computed tomography (CT) (popularly referred to as multicolor CT), used in combination with a gold high-density lipoprotein nanoparticle contrast agent (Au-HDL), for characterization of macrophage burden, calcification, and stenosis of atherosclerotic plaques.

Materials and Methods: The local animal care committee approved all animal experiments. A preclinical spectral CT system in which incident x-rays are divided into six different energy bins was used for multicolor imaging. Au-HDL, an iodine-based contrast agent, and calcium phosphate were imaged in a variety of phantoms. Apolipoprotein E knockout (apo E-KO) mice were used as the model for atherosclerosis. Gold nanoparticles targeted to atherosclerosis (Au-HDL) were intravenously injected at a dose of 500 mg per kilogram of body weight.