Typical behaviors of rabid skunks were entering a dog pen, appearing outside during daytime, and attacking pets.
Conclusions and Clinical Relevance-Information on the epidemiology of rabies in skunks may be useful in planning and implementing local, state, and national rabies control and prevention campaigns. (J
Am Vet Med Assoc 2009;234:616-620)”
“In order to clarify the mechanisms of reproductive toxicity in a QSAR approach, the transcriptional signatures upon the 2 day exposure to the 28 days EC50 of a series of increasingly chlorinated aniline compounds and 1,2,3,4-tetrachlorobenzene were measured in Folsomia candida. In general, the transcriptional patterns DMXAA in vitro associated with all compounds revealed toxicity at FDA-approved Drug Library the cellular membranes and hence components of narcosis type I, but a principal component analysis revealed a deviating response by the pentachloroaniline and 2,3,5,6-tetrachloroaniline exposure. Moreover the expression of a subset of mainly biotransformation related genes showed a significant relationship with the logic,, which stresses the presence of narcosis type I. This was confirmed by GO term enrichment at the level of cellular component. Genes involved in the three phases of xenobiotic biotransformation exhibited strict compound specific transcription patterns, which may reflect biotransformation processes in F. candida. Additional
toxic mechanisms were especially observed for the 2,3,5,6-tetrachloroaniline, which possible works as an uncoupler or inhibitor of electron transport systems, which is revealed by the up-regulation of genes that encode different members of the electron transport chain. The aniline and 2,3,4-trichloroaniline exposure Selleck A 1331852 caused the induction of genes in the ROS defense system. Additional toxicity mechanisms were less clear, but they include the attack of microbial pathogens for the six other compounds and for 2,3,5,6-tetrachloroaniline an effect on mitochondrial protein folding. (C) 2011 Elsevier Ltd. All rights reserved.”
“Three unusual sesquineolignans
conchignans A (1), B (2), and C (3), together with two known compounds vanillin (4) and phloroglucinol (5), were isolated from the whole plants of Alpinia conchigera. Their structures were established by spectroscopic analysis, including 2D NMR spectroscopic techniques.”
“Objective-To compare values for tibial plateau angle (TPA) obtained in dogs by conventional and digital methods.
Design-Evaluation study.
Animals-37 dogs with stifle joint abnormalities.
Procedures-In all dogs, radiographs of both stifle joints were obtained by conventional and digital means. On conventionally acquired radiographs, TPA was measured with a protractor and fine-point pencil in accordance with standard guidelines. A software program was used to measure TPA on digitally acquired radiographs. Two viewers with different levels of experience performed all measurements 3 times.