Through this method, two trace compounds, a new lipopeptide, named arylomycin A6 (1), and a known lipopeptide (arylomycin A5, 2) were found and isolated from an actinomycete Streptomyces parvus HCCB10043. The structure of the new lipopeptide was elucidated by a combination of 1D, 2D NMR (correlation spectroscopy, heteronuclear multiple quantum correlation and heteronuclear multiple bond coherence) techniques, high-resolution electrospray ionization mass spectrometry and MS/MS spectrometry and fatty TPX-0005 chemical structure acid analyses. Arylomycin A6 exhibited antibacterial activity against Staphylococcus epidermidis HCCB20256 with the minimum inhibitory
concentration of 1g/mL. Till now, arylomycins are the third series of active secondary metabolites we found in S. parvus HCCB10043. The results strongly support and encourage the studies for mining trace natural active products from microorganisms like Streptomyces.”
“A new oleanane-type triterpenoidal saponin, 3-O–d-glucopyranosyl-hederagenin 23-O–d-ribofuranoside (1), was isolated from the roots of Pulsatilla chinensis, and its structure was established
on the basis of the spectral data. Compounds 2, 7 and 8 showed moderate cytotoxic activity by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliumbromide assay.”
“In this article, particle swarm optimization (PSO) was applied to extract the solar cell parameters HSP phosphorylation from illuminated current-voltage characteristics.
The performance of the PSO was compared with the genetic algorithms (GAs) for the single and double diode models. Based on synthetic and experimental current-voltage data, it has been confirmed that the proposed method can obtain higher parameter precision with better computational efficiency than the GA method. Compared with conventional gradient-based methods, even without a good initial guess, the PSO method can obtain the parameters of solar cells as close as possible to the practical parameters only based on a broad range specified for each of the parameters. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3122082]“
“Background: Mutations and loss of the von Hippel-Lindau (VHL) tumor suppressor gene are associated with HSP990 in vivo most renal cancers as well as several other types of human tumors, but the potential role of the VHL protein (pVHL) in patients with chondrosarcoma has not been characterized. The purpose of the present study was to investigate the expression profiles of pVHL in chondrosarcoma and its association with clinicopathologic parameters, Bax expression, the apoptosis index, and overall survival of patients with chondrosarcoma.
Methods: The messenger RNA (mRNA) and protein levels of VHL in fresh specimens from eight chondrosarcomas were studied with use of real-time polymerase chain reaction and Western blot, respectively.