This is in stark contrast to the male, who can produce upwards of 100 million sperm a day. Changes in Sexual Function in the Aging Male Studies have consistently shown that increasing male age is associated with an increased time to pregnancy and scientific assays Decreased pregnancy rates. However, only a few studies have examined these outcomes while adjusting for female

Inhibitors,research,lifescience,medical age. Ford and colleagues performed a secondary data analysis of the Avon Longitudinal Study of Pregnancy and Childhood, a large population-based study in the United Kingdom. Surveys from 8559 pregnancies were used to determine the effect of age on time to pregnancy. After adjusting for female age, conception during a 12-month period was 30% less likely for men over age 40 years as compared with men younger than age 30 years.9 In addition to female age, coital frequency and sexual Inhibitors,research,lifescience,medical functioning are variables that affect time to conception and pregnancy rates. Decreased sexual activity can decrease the chances of conception,10 and erectile dysfunction Inhibitors,research,lifescience,medical (ED) increases with age.11 Decreased coital frequency with age is due in part to diminished sexual functioning; however, sexual dysfunction itself has no known influence on germ cells and its impact on infertility

can be overcome by measures of assisted reproductive technology.12 In a study of 1290 men aged 40 to 70 years who enrolled in the Massachusetts Male Aging Study (MMAS), sexual functioning and coital frequency were assessed. Between ages 40 and 70, the probability of having severe ED increased threefold and the probability of moderate ED increased twofold.13 In the same

cohort followed for an average of 9 years, coital frequency was assessed in 1085 men. After adjusting for JAK1/2 inhibito baseline sexual Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical function, men engaged in sexual activity an average of 6.5 times per month prior to age 40. This frequency decreased by one to two times per month after age 50 and by another one to two times per month after age 60.14 In a survey study of 1976 British women controlled for female age, coital frequency, social history, and weight, an even stronger age effect on pregnancy rate was found than in the study by Ford and colleagues. This study reported a five times greater increase Dacomitinib in time to pregnancy in men aged 45 years and older compared with men aged < 25 years. The increased time to pregnancy was similar even when restricting the analysis to men whose female partners were aged < 25 years.15 To evaluate pregnancy rates in different age groups, a French study examined 901 cycles of intrauterine artificial insemination. They found that the most significant factor contributing to probability of pregnancy was the age of the male partner. After six cycles, men aged ≥ 35 years had fertility rates of 25% compared with fertility rates of 52% in men aged < 35 years, representing a 52% decrease in fertility rate.