The transcriptional activation of reporter

genes in response to hypoxia is independent of potential HIF-1a-responsive element, located between -86 and -82 regions. HIF-1a overexpression significantly activated survivin expression. Conclusion: Our results demonstrate that survivin expression is upregulated following the induction of HIF-1a by hypoxia resulting from tumor formation, possibly leading to tumor progression. These findings have potential implication in developing novel cancer therapy targeting HIF-1.”
“Aim: To evaluate the feasibility of the see and treat protocol for the management of high-grade cervical intraepithelial neoplasia PF-03084014 inhibitor (CIN) at a colposcopy clinic in Bangladesh. Material and Methods: A cross-sectional and comparative study was carried out between two periods on 358 colposcopy-diagnosed high-grade CIN at the colposcopy clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU). During the first period (January 2005 to June 2008), 181 colposcopy-diagnosed high-grade CIN patients had cervical biopsy by punch biopsy forceps and histology-confirmed high-grade CIN were treated by loop electrosurgical excision procedure (LEEP). During

the second period (July 2008 to December 2009), 177 colposcopy-diagnosed high-grade CIN were treated by LEEP at their first visit. Results: During the first and second periods, 48 of 87 and 55 of 73 histology-proven high-grade CIN cases, respectively, Torin 2 in vivo received treatment. Among the study population, 37.3% women who had normal or CIN-I in histology were treated unnecessarily in the second period. The compliance of treatment improved by 20% and failure to receive treatment fell by 20%; these changes were statistically significant (P = 0.006). Conclusion:

See and treat protocol is a well-accepted, feasible and useful option for management of high-grade CIN in Bangladesh. It reduces the number of visits to the clinic and failure to receive treatment.”
“Aim: Considering that Selleckchem AZD6244 Ki-67 is a proliferative marker in molar pregnancies and the possible progression of these kinds of pregnancies to gestational trophoblastic neoplasia (GTN), we decided to evaluate the rate of expression of this marker in patients with uneventful hydatidiform moles and GTN. Moreover, we determined the predictive value of this factor for the progression of molar pregnancies to GTN. Methods: In two groups of patients, including 30 patients with uneventful molar pregnancies and 30 patients with GTN, an immunohistochemical staining technique using the Envision method was performed. To evaluate nuclear immunoreactivity of trophoblastic cells for Ki67 on paraffin sections obtained from molar pregnancy products, the percentage of the stained cells was used. Semi-quantitative evaluation was also performed. Data were analyzed using MannWhitney tests and receiver operating characteristic curve analysis.