The development and validation processes were consistent with AZD6094 the recommendations in the 2009 FDA Patient Reported Outcomes Guidance to Industry.

Results: Focus group participants described 2 distinct types of pain (intermittent and continuous), which they felt were relevant and important to monitor. Participants also indicated that pain and bleeding/spotting associated with intercourse were important symptoms related to endometriosis. Cognitive

interviews with additional endometriosis patients served to optimize item content, wording, and response options. Psychometric analyses found the EPBD items to behave as expected, for example, item-level means for subjects with severe endometriosis symptoms were higher (i.e., worse) compared with subjects with mild symptoms. Item-total correlations for the EPBD pain items (range 0.40-0.89) indicated that the items were related but not redundant. EPBD pain ratings correlated highly with the modified Brief Pain Inventory-Short Form Pain Intensity score (range 0.46-0.61). Women with severe endometriosis symptoms reported significantly higher intermittent and continuous dysmenorrhea and intermittent and continuous pelvic pain ratings Semaxanib order and greater interference with daily activities compared with women with mild symptoms (all p < 0.01).

Conclusions: The results of this study show that

the 17-item EPBD reliably and validly characterizes the types of pain that endometriosis patients identified as being important. As a daily patient-reported assessment, it overcomes the significant potential for intra-and inter-rater variability and rater and recall bias that is inherent in the Biberoglu and

Behrman Scale. Additional studies are required to confirm the dimensionality and optimal scoring of the EPBD, to corroborate the present results, and to assess other important measurement properties, such as responsiveness.”
“ObjectiveAttention for the expanding group of cancer survivors at work, and the late effects they are confronted with while working, has been limited. The objective of this systematic review is to identify https://www.sellecn.cn/products/chir-98014.html and summarize studies, exploring ongoing physical and/or psychosocial problems related to functioning of employees with a history of cancer, beyond their return to work.

MethodsPublications were identified through computerized Medline, Psychinfo, Embase, and Cinahl searches (January 2000-March 2013). Studies had to be directed at cancer survivors, who were employed during the study. Both qualitative and quantitative studies were included. Quality assessment of these studies was performed. Two reviewers independently extracted data from each publication, e.g., physical and/or psychosocial problems (e.g., fatigue and cognitive limitations), outcome measures (e.g., work productivity), and qualitative and quantitative results.

ResultsThe search identified 8979 articles.