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“Background Optical microcavities with tubular geometry exhibit several advantages compared to
other types of optical microcavities [1–4]. They naturally assume a hollow structure and are fully www.selleckchem.com/products/su5402.html integrative into lab-on-chip systems . In the past years, rolled-up tubular microcavities have been used as cell culture devices [6, 7], microlasers [8, 9], sensors , and so on. Especially, rolled-up microcavities with (ultra)thin wall thickness are sensitive to tiny alterations and modifications in the vicinity Astemizole of the inner and outer tube wall surfaces . Thus, the microcavities exhibit excellent
potential applications as sensors in the fields of optoelectronics , biosensing [6, 12], and integrated optofluidics [10, 13]. Very recently, preliminary results concerning detection of dynamic molecular processes were demonstrated on a self-rolled-up SiO/SiO2 optical microcavity with sub-wavelength wall thickness . In fact, the molecule absorption/desorption are quite complex processes, and their interaction with the evanescent field is even intricate, especially in the nanoscale. Before this sensing technique can be put into practical applications like other label-free methods, more work must be done to disclose the mechanism and to exhibit the general and diverse capability of the approach. In this letter, we focus on the detection of physically and/or chemically absorbed water molecules by using a rolled-up tubular microcavity as a core component. The microcavities used in this work were prepared by releasing prestressed 33.5-nm-thick Y2O3/ZrO2 circular nanomembranes on photoresist sacrificial layers. The influence of surface composition (e.g.