complications of the donors were graded according to the Clavien classification. www.selleckchem.com/Akt.html Results: There were 45 donors (7%) with Gilbert’s syndrom in a mean age of 33 years. The control group consist of 99 donors by a mean age of 32 years. All patients received the right lobe of their donor. There were no intraoperative complications. The comparison of the two groups have shown that there are no significant differences in age, remnant ratio, intra- or postoperative complications, AST-, ALT-, INR- levels, hospital stay or survival. However the postoperative bilirubin levels at day 1-7, the maximal peak bilirubin level and the level one and six month after transplantation are significantly higher in donors with Gilbert’s syndrome compared to non-Gilbert’s donors (Table 1). There were no donor death in our series. Conclusion: Although BVD-523 concentration the bilirubin levels are significantly higher in donor with Gilbert’s syndrome compared to non-Gilbert’s group, the results do not show any clinical importance. Based on the results of our study we can conclude that donor with Gilbert’s syndrome can be accepted safely for living donor liver transplantation without increased risk. p:0.000, student T test, for all Disclosures: The following people have nothing to disclose:
Murat Akyildiz, Gokhan Gungor, Necdet Guler, Arzu Oezcelik, Tonguc Utku Yilmaz, Onur Yaprak, Yalcin Erdogan, Murat Dayangac, Yildiray Yuzer, Yaman Tokat Purpose: Laparoscopic liver resection (LLR) has been shown to be safe and efficacious
in the management of liver masses in adults, however, little literature DCLK1 exists describing the feasibility of and approaches to LLR in children. Additionally, the indications for LLR have typically excluded large lesions (>5 cm) and masses in the posterior and superior segments of the liver, due to technical limitations. We present our experience with LLR for liver lesions in the pediatric population, including large tumors, masses in difficult locations, and major hepatic resection. Methods: After IRB approval, we retrospectively reviewed LLR patients treated at our institution from 2009 – 2012. Data collected included demographics, clinical presentations, radio-graphic studies, intraoperative details, and postoperative complications and outcomes. Results: Six LLR procedures were performed in children (2 males, 4 females) presenting between 5 – 21 years of age. Maximal tumor diameter ranged from 3.1 – 10 cm (mean, 5.7 cm). Indications for resection included enlarging mass and/or right upper quadrant pain. Operative approaches included pure laparoscopy (n = 3) and hand-assisted laparoscopy (n = 3). Laparoscopic ultrasound was utilized in all patients to delineate resection margins and major intrahepatic vasculature. Techniques utilized for parenchymal transection included electrocautery, Harmonic scalpel, CUSA ultrasonic dissection, and endoscopic surgical staplers.