Patents disclosing preparation methods of extracts and purified pharmaceutical

isolates are reviewed, and examples of anti-cancer formulations, used as pharmaceuticals or nutraceuticals, are given. The review suggests that according to the present understanding, the anti-cancer activity of G. lucidum may be attributed to at least five groups of mechanisms: (1) activation/modulation of the immune find more response of the host, (2) direct cytotoxicity to cancer cells, (3) inhibition of tumor-induced angiogenesis, (4) inhibition of cancer cells proliferation and invasive metastasis behaviour, and (5) carcinogens deactivation with protection of cells. Although, the data from recent in vitro GDC-0068 clinical trial and in vivo studies demonstrate promising anti-cancer effects, a need is identified for further (1) isolation and purification of compounds, with deeper understanding of their individual and synergistic pharmacological effects, (2) molecular level studies of the antitumor and immuno-supportive mechanisms, (3) well designed in vivo tests and controlled clinical studies, and (4) standardisation and quality control for G. lucidum strains, cultivation

processes, extracts and commercial formulations.”
“Importance of the field. Nuclear factor kappa B (NF-kappa B) is activated by a variety of cancer-promoting agents. The reciprocal activation between NF-kappa B and inflammatory cytokines makes NF-kappa B important for inflammation-associated cancer development. Both the constitutive and anticancer therapeutic-induced NF-kappa B activation blunts the anticancer activities of the therapy. Elucidating the roles of NF-kappa B in cancer facilitates developing approaches for cancer prevention and therapy.\n\nAreas covered

in this review. By searching PubMed, we summarize the progress of studies on NF-kappa B in carcinogenesis and cancer cells’ drug resistance in recent 10 years.\n\nWhat the reader will gain: The mechanisms by which NF-kappa B activation pathways are activated; the roles and mechanisms of NF-kappa B in cell survival Erastin and proliferation, and in carcinogenesis and cancer cells’ response to therapy; recent development of NF-kappa B-modulating means and their application in cancer prevention and therapy.\n\nTake home message: NF-kappa B is involved in cancer development, modulating NF-kappa B activation pathways has important implications in cancer prevention and therapy. Due to the complexity of NF-kappa B roles in different cancers, careful evaluation of NF-kappa B’s in each cancer type is crucial in this regard. More cancer cell-specific NF-kappa B inhibiting means are desired for improving anticancer efficacy and reducing systemic toxicity.”
“Vitiligo can be treated using various new and experimental therapies, such as narrow-band ultraviolet B microphototherapy (NB-UVB), narrow-band ultraviolet B excimer laser and monochromatic excimer light.