Non-statin lipid-lowering drugs have their own unique limitations. Management strategies and algorithms for statin-associated toxicities are available to help guide clinicians. Clinical practice should emphasize tailoring therapy to address each individual’s cholesterol goals and risk of developing adverse effects on lipid-lowering drugs.

(C) 2014 Elsevier Ltd. All rights reserved.”
“Limited pharmacological options are available for management pediatric hypertriglyceridemia. We examined the effectiveness Selleckchem P5091 of dietary fish oil supplementation as a means to reduce triglyceride levels in pediatric patients. We reviewed 111 children aged 8 to 18 years with hypertriglyceridemia ( bigger than = 1.5 mmol/L) undergoing treatment in a specialized dyslipidemia clinic. At the treating cardiologist’s discretion, 60 subjects received nonprescription fish oil supplementation (500-1000 mg/d), while the remaining patients did not. Initially there were no baseline differences between groups, including the use of

concomitant lipid-lowering medication. Treatment with fish oil was associated with a potential clinically relevant but non-statistically significant decrease in triglycerides and triglyceride-tohigh- density lipoprotein (HDL) ratio. Fish oil had no effect on HDL-cholesterol, Sapanisertib order non-HDL-cholesterol, or total cholesterol. All associations remained unchanged when adjusted for body mass index z score, nutrition, physical activity, and screen time. Fish oil supplementation was not significantly effective in treating hypertriglyceridemia in pediatric patients.”
“Background & objectives: Emblica PD173074 officinalis (amla), which is a good source of vitamin C, has been shown to be beneficial due to its immune system enhancing property coupled with its tonifying and antiageing effect. The present study was conducted to evaluate the effect of E. officinalis feeding on the susceptibility of experimental mice to respiratory tract infection induced by Klebsiella pneumoniae.\n\nMethods: The effect

of short – (15 days) and long (30 days) – term feeding of amla in mice on the course of K. pneumoniae ATCC43816 infection in lungs was studied, in terms of bacteria[ colonization, macrophage activity, malondialdehyde (MDA) and nitrite production in broncheoalveolar lavage fluid (BALF). Tumour necrosis factor (TNF) -alpha level in serum was also assessed.\n\nResults: Though there was a decrease in bacterial colonization after short-term feeding, it was not significant. On the contrary, the decrease in bacterial load was significant (P<0.05) on long-term feeding. The operative mechanisms in terms of lipid peroxidation, phagocytosis and nitrite production were studied by estimating their levels in broncheoalveolar lavage fluid (BALF).