Methods: We analyzed 118 consecutive patients with ALD who performed colonoscopy between January 2000 and December 2013. For each case, age – (±5 years) and sex-matched controls were identified from patients with non-alcoholic fatty liver disease (NAFLD) and healthy controls. Clinical characteristics were reviewed through medical records, colonoscopic finding, pathologic finding, images. Results: The prevalence of colorectal cancer was LY294002 ic50 6 (5.1%) in ALD patients, 5 (2.5%) in

NAFLD patients, 0 (0.0%) healthy control (P = 0.007). In addition, the prevalence of advanced colonic adenoma was 18 (15.3%) in ALD patients, 17 (8.6%) in NAFLD, in 6 (2.8%) healthy control (P < 0.001). A case-control study showed that odds for detecting a colorectal advanced neoplasm among ALD patients without decompensated liver cirrhosis were approximately 10.1 times greater than in healthy controls [OR,10.095; 95% Confidential interval (CI),

3.638-28.014; P < 0.001) ]. There was no significant difference in the prevalence of colorectal cancer (P = 0.428) and advanced colonic adenoma (P = 0.876) according to the presence of decompensated liver cirrhosis (LC) in ALD patients. LDK378 Age is an independent risk factor for detecting advanced colonic neoplasm in patients with ALD [OR, 1.091; 95% CI, 1.025-1.162; P = 0.007] Conclusion: The yield for detecting advanced neoplasm was significantly higher in patients with ALD than in healthy control. Screening for colorectal neoplasm using colonoscopy is warranted in ALD patients without decompensated LC. Key Word(s): 1. alcoholic liver disease; 2. advanced colonic neoplasm; 3. decompensated

liver cirrhosis Presenting Author: MYUENG GUEN OH Additional Authors: MAN WOO KIM, CHAN GUK PARK, YOUNG DAE KIM, JUN LEE, MI AH HAN Corresponding Author: MYUENG GUEN OH Affiliations: PAK5 Chosun University Hospital, Chosun University Hospital, Chosun University Hospital, Chosun University Hospital, Chosun University Objective: This study was performed to investigate the association between coffee and serum aminotransferase in Korean adults. Methods: Data were obtained from the 4th and 5th Korea National Health and Nutrition Examination Survey. Elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were defined as >30 IU/L for men and >19 IU/L for women, respectively. Proportion of elevated ALT and AST according to general characteristics and coffee consumption frequency were tested by chi-square tests. Adjusted odds ratios (aOR) and 95% confidence interval (CI) for elevated ALT and AST by coffee consumption frequency were calculated after adjusting for sex, age, smoking status and body mass index.