J Thorac Oncol 2009, 4:1104–1110.PubMedCrossRef 39. Blasberg JD, Pass HI, Goparaju CM, Flores RM, Lee S, Donington JS: Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancer. J Clin Oncol 2010, 28:936–941.PubMedCrossRef Tanespimycin 40. Wu J, Pungaliya P, Kraynov E, Bates B: Identification and quantification of osteopontin splice variants in the plasma of lung cancer patients using immunoaffinity

capture and targeted mass spectrometry. Biomarkers 2012, in press. 41. Politi K, Pao W: How genetically engineered mouse tumor models provide insights into human cancers. J Clin Oncol 2011, 29:2273–2281.PubMedCrossRef 42. DuPage M, Dooley AL, Jacks T: Conditional mouse lung cancer

models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protoc 2009, 4:1064–1072.PubMedCrossRef 43. Kiefer FW, Neschen S, Pfau B, Legerer B, Neuhofer A, Kahle M, Hrabe de Angelis M, Schlederer M, Mair Dabrafenib in vitro M, Kenner L, Plutzky J, Zeyda M, Stulnig TM: Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. Diab tologia 2011, 54:2132–2142.CrossRef 44. Liaw L, Birk DE, Ballas CB, Whitsitt JS, Davidson JM, Hogan BL: Altered wound healing in mice lacking a functional osteopontin gene (spp 1). J Clin Invest 1998, 101:1468–1478.PubMed ADAM7 45. Crawford HC, Matrisian LM, Liaw L: Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo. Cancer Res 1998, 58:5206–5215.PubMed 46. Nemoto H, Rittling SR, Yoshitake H, Furuya K, Amagasa T, Tsuji K, Nifuji A, Denhardt DT, Noda M: Osteopontin deficiency

reduces experimental tumor cell metastasis to bone and soft tissues. J Bone Miner Res 2001, 16:652–659.PubMedCrossRef 47. Chakraborty G, Jain S, Patil TV, Kundu GC: Down-regulation of osteopontin attenuates breast tumour progression in vivo. J Cell Mol Med 2008, 12:2305–2318.PubMedCrossRef 48. Zhao B, Sun T, Meng F, Qu A, Li C, Shen H, Jin Y, Li W: Osteopontin as a potential biomarker of proliferation and invasiveness for lung cancer. J Cancer Res Clin Oncol 2011, 137:1061–1070.PubMedCrossRef 49. Goparaju CM, Pass HI, Blasberg JD, Hirsch N, Donington JS: Functional heterogeneity of osteopontin isoforms in non-small cell lung cancer. J Thorac Oncol 2010, 5:1516–1523.PubMedCrossRef 50. Chang YS, Kim HJ, Chang J, Ahn CM, Kim SK: Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer. Lung Cancer 2007, 57:373–380.PubMedCrossRef 51. Blasberg JD, Goparaju CM, Pass HI, Donington JS: Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity. J Thorac Cardiovasc Surg 2010, 139:1587–1593.PubMedCrossRef 52.