FA authored the manuscript. EB edited the manuscript. EB provided patient care. TD was the attending physician who cared for the patient, instigated the study, edited the manuscript, and oversaw the project. All authors read and approved the final manuscript.”
“Introduction Injury is a major public health problem in terms of mortality, morbidity and disability and it has been largely demonstrated that the organisation of a regionalised EVP4593 purchase trauma System significantly decreases the deleterious impact of severe trauma on population [1, 2]. In Europe the inclusive trauma system model has gained dominance.

In this Ruboxistaurin nmr model a network of hospitals with different resources takes care of trauma patients suffering from any among the full spectrum of injuries [3]. Epidemiologic information based on the entire population in a given region and understanding the number of severely injured VEGFR inhibitor that need to be admitted to a level one hospital, is of pivotal importance in the design of an inclusive Trauma System. With this objective, methodological approaches in measuring incident rates should use large representative samples of the whole population, to offer the potential to observe data on all the people living

in a region or a nation. Trauma registries contain detailed information, but this is offset by the limitation of including only patients treated at trauma centre and already triaged as “severe” at a dedicated trauma unit. On the contrary, population-based registries have usually been recorded for many years and are

available for time periods before changes of the Healthcare system. Additionally, they contain readily available, alphanumeric-coded information and allow easy and low cost analysis. Moreover, population-based registries may be used to investigate resources consumption and evaluate costs of the system. Recently, many investigators have started to use large databases for quality assessment studies in trauma care, and these works are classified as providing “high end” Class III evidence [4–8]. The objective of this study was to perform an exhaustive analysis of severe trauma patients hospitalised in Lombardia, a mixed rural/industrial region of northern Italy. Mirabegron The hospital discharge registry, a population-based record of all hospitalised people of the country, has been used as source of data. All hospital admissions for injuries during a three years period have been included and severely injured patients have been extrapolated. This analysis may be a useful starting point for evaluating the need for resources and costs of regional Trauma System implementation. Methods Lombardia is a mixed rural/industrial region of the northern Italy, with an area of 24,000 Km [2] (9,302 square miles), with Alpi Mountains in the north and hill or flat in the south. Residents, evaluated at the end of 2010, were 9,737,074 (1,046 persons per square mile), 48.87% males, and Milano is the capital city.