Conflict of Interest: None declared
Background: There is yet

Conflict of Interest: None declared
Background: There is yet a dearth of literature on the antifertility effect of Momordica charantia on the male reproductive system. The aim of this study was to determine the effect of graded oral doses of methanolic seed extract of Momordica charantia on the histology of prostate gland and seminiferous tubules of rats. Methods: Forty male Sprague-Dawley rats, weighing 176±7 g were assigned randomly into four main groups A to D of 10 rats per group. Groups A to C received daily oral doses of15, 25 or 50 mg/100 g body weight of the seed extract for 56 days. Group D (control) received physiological saline. In each group, five rats were sacrificed

Inhibitors,research,lifescience,medical on day 57, the remaining half Inhibitors,research,lifescience,medical on day 113 (56 days after withdrawal of the extract). The testes and prostate were processed for histological examination. Results: There was a dose-related alteration in the cytoarchitecture of seminiferous tubules with marked reduction in spermatogenic series. The prostate gland showed dilatation as well as increased intraluminal secretions with increasing dose. Moreover, there Inhibitors,research,lifescience,medical was a significant recovery of prostate tissue

as the sections were similar to their HDAC inhibitor control counterpart. Conclusion: the findings of the present study indicate that methanolic extract of Momordica charantia seeds caused reversible histological alterations in the prostate and testes of Sprague-Dawley rats. Key Words: Momordica charantia, Sprague-Dawley rats, prostate, testes, seminniferous tubules Introduction There is currently a shift in the consumption of synthetic formulations to medications prepared from natural

product. The insufficiency of current therapies to combat some ailments, combined with Inhibitors,research,lifescience,medical the lack Inhibitors,research,lifescience,medical of trust in conventional remedies and an inability of the economy to afford the cost of synthetic medicines accounts for the growing public interest in the natural products.1,2 There has also been a great fascination for herbal medicines and dietary food supplements in the developed countries, since they are believed to possess minimal side effects.3 In the same vein, there has been a rise in the incidence of male infertility today as supported by growing evidence from clinical and epidemiological studies.4,5 Earlier investigations have, however, implicated certain locally-consumed ethnopharmacological preparations/extracts Linifanib (ABT-869) as a positive source of environmental toxicants that may contribute to decline in male fertility.6 Some other etiological aspects are still under investigation, and the knowledge of exogenous factors affecting the male reproductive system still limited. Momordica charantia (MC) is a plant that has gained popularity in recent years. It is widely consumed in about 8-10 countries and at least in two continents as an ethnopharmacological preparation.7 It is indicated in the management of diabetes mellitus, and several other ailments in these countries.

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