A total of 293 patients (57%) responded, with an average age of 60 years and a median interval from surgery of 12 months. Of the respondents, 75% completed the survey within 4 days of receiving the electronic GSK1838705A mail, with a median completion time of 15 minutes. The total survey administration
costs were limited to the web site’s $200 annual fee-for-service.\n\nCONCLUSIONS An online survey can be a low-cost, efficient, and confidential modality for assessing validated HRQOL outcomes in patients who undergo treatment of localized prostate cancer. This method could be especially useful for those who cannot return for follow-up because of geographic reasons. UROLOGY 79: 314-320, 2012. (C) 2012 Elsevier Inc.”
“We consider single particle and polymer translocation where the frictional properties experienced from the environment are changing in time. This work is motivated by the interesting frequency responsive behaviour observed when a polymer is passing through a pore with an oscillating width. In order to explain this better we construct general diffusive and non-diffusive frequency response of the gain in translocation JQ1 chemical structure time for a single particle in changing environments and look at some specific variations. For two state confinement, where the particle either has constant drift velocity or is stationary, we
find exact expressions for both the diffusive and non-diffusive gain. We then apply this approach to polymer translocation under constant forcing through a pore with a sinusoidally varying width. We find good agreement for small polymers at low frequency oscillation with deviations occurring at longer lengths and higher frequencies. Unlike periodic forcing of a single particle at constant mobility, constant forcing with time dependent mobility is amenable to exact solution through manipulation of the Fokker-Planck equation. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4767527]“
“BackgroundThe association between obesity and bronchial hyperreactivity (BHR) in children has not been fully demonstrated in
cross-sectional or longitudinal studies, and no study has specifically addressed Latino children.\n\nMethodsA cross-sectional study of 450 children (10-18 years) from public schools was conducted in Mexico city. Among Smoothened inhibitor this group, 260 met the study criteria (no chronic respiratory illnesses, including asthma and rhinitis; no acute respiratory infections; and no tobacco-exposure or endocrine or body dysmorphic disorders), and 229 performed reproducible pulmonary function and methacholine challenge tests and were fully analyzed.\n\nResultsAccording to BMI percentiles, 40 were normal weight, 116 were obese, and 73 morbidly obese. Children in the morbidly obese group had significantly higher % FVC than those in the normal-weight group, and obese children had higher % PEF those in the morbidly obese and normal-weight groups.