[48] French Bordeaux from the left margin of the Gironde River are richer in tannins because they have a minimum of 75% Cabernet Sauvignon grapes. They usually are complex and very good wines with a high potential from aging. Cabernet Sauvignons from South America have also improved in quality in recent years. In a study the authors of this review article conducted, we evaluated 28 regular patients (14 women

and 14 men, ages 25 to 67 years, mean 54.5) from the Headache Center of Rio under various preventive treatments, who were also self-considered wine drinkers and reported a clear-cut relationship between wine intake and a headache attack. They were all migraineurs according to the ICHD-II.[40] The patients took two half bottles of any French and any South American Cabernet Sauvignons (minimum Crizotinib supplier 4 days between wines). French wines had to be from the Medoc or Haut Medoc regions, specified in the bottle label. A detailed headache calendar had to be filled out, and any headache attack within 12 hours had to be reported. http://www.selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html No other alcohol source and no more than 375 mL were allowed during the study. Twenty-three patients (13 women and 10 men) completed

the study. French wine ingestion triggered a migraine attack more often than reporting in the South American wines (Table 2). Four patients had no attacks, and 4 patients presented attacks with both wines. Five patients reported a migraine attack after the South American Cabernet but not with the French Cabernet. None of the patients from the last 2 studies had a headache attack not fulfilling MCE migraine after the wine ingestions. Cabernet Sauvignon is one of the world’s most widely recognized red wine grape varieties. It is grown in nearly every major wine producing country among a diverse spectrum of climates. This grape became internationally recognized through its prominence in Bordeaux wines where it is often blended with Merlot and Cabernet Franc in amounts varying with the region

in which it is produced. Although well known among wine producers and consumers, the Cabernet Sauvignon is relatively new, representing a chance crossing between Cabernet Franc and Sauvignon Blanc during the 17th century in southwestern France.[49, 50] The Cabernet Sauvignon is a very small grape with a thick skin, creating a high 1:12 ratio of seed to fruit.50-52 This results in the high proportions of phenols and tannins observed in this wine, especially if the must is subjected to long periods of maceration (skin contact) before fermentation. In Bordeaux, the maceration period is traditionally 3 weeks, which results in very tannic and flavorful wines that require years of aging. Reducing the maceration time to as a little as a few days, may create light and more approachable wines as with some South American wine makers.