24, IC 95% 1.02-1.51). The genotypes -174 GC/CC and -572 GG may confer susceptibility for the development of subclinical inflammation and type 2 diabetes in selleck inhibitor Mexican families.”
“Objectives: To evaluate the prevalence and
the risk factors for cervical intraepithelial neoplasia (CIN) among HIV-infected women.
Methods: Cross-sectional study of 494 HIV-infected women in Brazil, between 1998 and 2008. Gynecologic exam was performed, and samples were collected for cervical cytology and for HPV DNA detection. Cervical biopsy was carried out when indicated. HPV infection, CD4 T-lymphocyte count and HIV viral load were compared with cervical histopathology. Univariate and multivariate statistical analyses were performed to evaluate the statistical association of several risk factors.
Results: CIN prevalence detected by histopathology was 23.4% (6% of CIN2/3 and 17.4% cases of CIN1). Multivariate analysis confirmed an independent association of CIN with CD4 T-lymphocyte count below 200 cells/mm(3) (OR 5.0, 95% CI 2.5-10.1),
with a positive detection of HPV DNA (OR 2.0, 95% CI 1.2-3.5), and with age <= 34 years old (OR 1.5, 95% CI 1.0-2.4). HIV viral load and antiretroviral MEK inhibitor clinical trial use were not independent risk factors for CIN.
Conclusions: Severity of immunosupression, presence of HPV infection and younger age are strong predictors of CIN among HIV-infected women. (C) 2012 Elsevier Editora Ltda. All rights reserved.”
“Our aim was to investigate whether a genetic variation in the corticotropin-releasing hormone receptor 2 gene might be associated with preterm birth. In this case-control study we evaluated the G/A polymorphism (rs2267717) in intron 2 of the corticotropin-releasing hormone receptor 2 gene in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth. No significant correlation was found between the presence of the investigated polymorphism and preterm birth (p = 0.9, selleck odds ratio 0.9 [Confidence interval 0.5-1.7]).
A dose dependent association of the investigated polymorphism, in women with preterm birth, with gestational age at delivery (p = 0.003) and birth weight was observed (p = 0.0001). However, no association between IUGR (n = 10) with either one of the investigated genotypes (p = 0.3) was found. Stratified analysis within case group (i.e. PPROM vs. non-PPROM) revealed no significant difference in genotype distribution (p = 0.6). In conclusion, the investigated polymorphism does not increase the risk for preterm birth overall but might modulate the length of pregnancy in a dose dependent fashion in a series of Caucasian women.”
“Objective: Phthalates and bisphenol A (BPA) are ubiquitous environmental toxicants, present in high concentrations in numerous consumer products. We hypothesized that maternal exposure to phthalates and BPA in pregnancy is associated with shortened gestation.