2. Materials and Methods 2.1. Materials Olmesartan medoxomil was received as a gift sample from Alembic Pharma Ltd., Baroda, India. The following materials were gifted by Abitec Corp., USA and were used as received: Capmul MCM (Glyceryl monocaprylate), Acconon C-80 (Polyoxyethylene 80 coconut glycerides), Captex 200 (Propylene glycol dicaprylocaprate),
and Captex 355 (Glyceryl tricaprylate). Plurol Oleique (Polyglyceryl-3 Inhibitors,research,lifescience,medical dioleate), Labrafil M 2125CS (Linoleyl macrogol-6 glycerides), and Lauroglycol 90 (Propylene glycol monolaurate) were received as gift sample from Gattefosse, France. Acrysol K 140 (Polyoxyl 40 hydrogenated castor oil) and Acrysol EL 135 (Polyoxyl 35 castor oil) were procured as a gift Inhibitors,research,lifescience,medical samples from Corel Pharma Chem., Ahmedabad, India. Fujicalin (Dibasic calcium phosphate anhydrous) and Neusilin (Magnesium aluminometasilicate) were obtained as gift sample from Fuji Chemical Industry Co. Ltd., Japan. 2.2. Solubility Studies Solubility of olmesartan medoxomil was determined Inhibitors,research,lifescience,medical in various nonvolatile solvents. Two mL of each component was taken in screw cap vials with known quantity (200mg) of excess drug. After sealing, vials were kept on isothermal mechanical shaker at 37 ± 2°C for 72 hours. After equilibrium, each test tube
was centrifuged at 6000rpm for 20 minutes. Supernatant was filtered through membrane filter using 0.45μm filter Inhibitors,research,lifescience,medical disk. Filtered solution was appropriately diluted with methanol, and UV absorbances were measured at 257nm wavelength. Concentration of dissolved drug was determined using standard equation. 2.3. Measuring Angle of Slide This experiment was designed to measure the flowable liquid retention potential (-value)
for Avicel PH 102, Fujicalin and Neusilin (carrier Inhibitors,research,lifescience,medical material, Ca), and Aerosil (coating material, Co) and the optimum liquid load factor (Lf). The -value of a powder is the maximum amount of given nonvolatile liquid that can be retained inside powder bulk (w/w) while maintaining acceptable flowability, whereas Lf is the mass ratio (w/w) of the liquid medication to the carrier powder in the liquisolid formulation. Powder admixtures containing 5g of either carrier or coating with increasing quantity of nonvolatile liquid vehicle (Acrysol EL 135) were mixed 3-mercaptopyruvate sulfurtransferase using a mortar and pestle. Each admixture was then placed on a shiny metal plate; the plate was then tilted until the admixture slides. The angle formed between the plate and the this website horizontal surface, at which admixture slides were measured as angle of slide (θ). The flowable liquid retention potential was calculated using the following equation: φ-Value=Weight of nonvolatile liquidWeight of carrier or coat. (1) Each admixture has specific -values which were determined and plotted against respective measured angle of slide for all nonvolatile liquid vehicles.