2 85 8 106 1 3 20 1 78 5 298 1 2 18 3 80 4 404 4 3 NT 0 0 10 0 90

2 85.8 106 1.3 20.1 78.5 298 1.2 18.3 80.4 404 4.3 NT 0.0 10.0 90.0 10 0.0 20.7 79.3 29 0.0 17.9 82.1 39 0.4 11F – - – - 0.0 16.7 83.3 6 0.0 16.7 83.3 6 0.1 15C 0.0 15.4 84.6 26 0.0 14.8 85.2 27 0.0 15.1 84.9 53 0.6 9A 0.0 9.5 90.5 21 0.0 19.2 80.8 26 0.0 14.9 85.1 47 0.5 33B 0.0 0.0 100.0 3 0.0 25.0 75.0 4 0.0 14.3 85.7 7 0.1 33A 0.0 11.1 88.9 9 0.0 14.3 85.7 21 0.0 13.3 86.7 30 0.3 33F 0.0 0.0 100.0 17 0.0 17.6 82.4 51 0.0 13.2 86.8 68 0.7 12B 0.0 0.0 100.0 3 0.0 20.0 80.0 5 0.0 12.5 87.5 8 0.1 6A 0.0 5.5 94.5 128 0.4 9.7 89.9 277 0.2 8.4 91.4 405 4.3 28A 0.0 0.0 100.0 4 0.0 12.5 87.5 8 0.0 8.3 91.7 12 0.1 35F 0.0 10.0 selleck chemicals 90.0 10 0.0 7.8

92.2 64 0.0 8.1 91.9 74 0.8 24F 0.0 6.8 93.2 44 0.0 6.9 93.1 72 0.0 6.9 93.1 116 1.2 13 0.0 0.0 100.0 3 0.0 8.3 91.7 Selleck MLN0128 12 0.0 6.7 93.3 15 0.2 16F 0.0 0.0 100.0 7 3.7 7.4 88.9 27 2.9 5.9 91.2 34 0.4 17F 0.0 12.5 87.5 8 0.0 3.2 96.8 31 0.0 5.1 94.9 39 0.4 38 0.0 0.0 100.0 23 0.0 7.9 92.1 38 0.0 4.9 95.1 61 0.6 34 0.0 16.7 83.3 6 0.0 0.0 100.0 15 0.0 4.8 95.2 21 0.2 9N 0.0 0.0 100.0 25 0.0 5.5 94.5 145 0.0 4.7 95.3 170 1.8 11A 0.0 0.0 100.0 15 0.0 5.2 94.8 135 0.0 4.7 95.3 150 1.6 18A 0.0 0.0 100.0 10 0.0 8.3 91.7 12 0.0 4.5 95.5 22 0.2 1 0.4 5.2 94.4 232 0.2 3.5 96.3 458 0.3 4.1 95.7 690 7.3 7F 0.0 3.9 96.1 203 0.4 3.7 95.9 515 0.3 3.8 96.0 718 7.6 5 0.0 0.0 100.0 19 0.0 5.4 94.6

37 0.0 3.6 96.4 56 0.6 10A 0.0 4.0 96.0 50 0.0 2.5 97.5 122 0.0 2.9 97.1 172 1.8 4 0.0 2.9 97.1 102 0.0 2.2 97.8 409 0.0 2.3 97.7 511 5.4 20 0.0 0.0 100.0 5 0.0 2.6 97.4 38 0.0 2.3 97.7 43 0.5 18C 0.6 1.7 97.8 181 0.0 2.8 97.2 145 0.3 2.1 97.5 326 3.5 3 0.0 3.1 Progesterone 96.9 96 0.2 1.8 98.0 663 0.1 2.0 97.9 759 8.1 12F 0.0 0.0 100.0 16 0.0 1.9 98.1 105 0.0 1.7 98.3 121 1.3 8 0.0 0.0 100.0 18 0.5 1.6 97.9 190 0.5 1.4 98.1 208 2.2 23A 0.0 0.0 100.0 14 0.0 1.4 98.6 74 0.0 1.1 98.9 88 0.9 22F 0.0 0.0 100.0

20 0.5 0.5 98.9 186 0.5 0.5 99.0 206 2.2 2 0.0 0.0 100.0 1 0.0 0.0 100.0 11 0.0 0.0 100.0 12 0.1 31 0.0 0.0 100.0 1 0.0 0.0 100.0 25 0.0 0.0 100.0 26 0.3 12A 0.0 0.0 100.0 3 0.0 0.0 100.0 9 0.0 0.0 100.0 12 0.1 18F 0.0 0.0 100.0 5 0.0 0.0 100.0 10 0.0 0.0 100.0 15 0.2 23B 0.0 0.0 100.0 6 0.0 0.0 100.0 11 0.0 0.0 100.0 17 0.2 35B 0.0 0.0 100.0 3 0.0 0.0 100.0 8 0.0 0.0 100.0 11 0.1 9L 0.0 0.0 100.0 5 0.0 0.0 100.0 12 0.0 0.0 100.0 17 0.2 Others* 0.0 0.0 100.0 31 0.0 0.0 100.0 62 0.0 0.0 100.0 93 1.0 not serotyped 0.0 4.4 95.6 45 0.2 0.0 99.8 2360 0.2 0.1 99.8 2405 – total (%) 0.2 23.8 76.1 – 0.3 13.4 86.3 – 0.2 16.0 83.7 – 100.0 total (n) 5 707 2261 2973 24 1184 7626 8834 29 1891 9887 11807 9402 I%, intermediate Adavosertib order isolates in percent; R%, resistant isolates in percent; S%, susceptible isolates in percent; n, number of isolates tested.

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