01), but transcriptome data showed no significant changes in genes related to cell cycle. Conclusions: Baseline

histology and hepatic gene expression differ according to clinical outcome in patients with AH. Higher liver macrophage expansion, increased proliferative hepatocyte and LPC number as well as up-regulation of cell proliferation related genes are associated see more with a favourable outcome (decrease in MELD score at 3 months). Stem cell transplantation has no effect on hepato-cyte proliferation. Disclosures: The following people have nothing to disclose: Nicolas Lanthier, Laura Rub-bia-Brandt, Nathalie Lin-Marq, Sophie Clement, Jean-Louis Frossard, Nicolas Goossens, Laurent Spahr “
“Metabolic syndrome (MS) is likely to be associated with non-alcoholic fatty liver disease (NAFLD). The prevalence of NAFLD in visceral fat type MS (V-type MS) is known to be higher than in subcutaneous fat type MS (S-type MS) in men with MS, and a larger subcutaneous fat area is reported to be not associated with NAFLD in women. We elucidated differences between V-type S-type MS in Japanese women with MS. The subjects were 276 women with MS who

underwent a medical checkup including abdominal ultrasonography. We examined for the prevalence of fatty liver and investigated biochemical parameters, and we also made a distinction between V-type and S-type MS. Triglyceride, uric acid, alanine PF-562271 in vivo aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase, the frequency of fatty liver and impaired glucose tolerance (IGT) were significantly higher in V-type learn more MS than in S-type MS. On logistic regression analysis with NAFLD (in our study,

fatty liver with ALT ≥31 IU/L was defined as NAFLD) as a dependent variable, body mass index, dyslipidemia, AST and V-type MS were significant predictors of an increased prevalence of NAFLD (odds ratios [OR] = 18.85, 3.119, 59.77 and 3.205; 95% confidence intervals [CI] = 3.585–99.15, 1.195–8.142, 18.03–198.2 and 1.198–8.573; P < 0.001, <0.05, <0.001 and <0.05, respectively). Women with V-type MS are more likely to have fatty liver, IGT and liver dysfunction than those with S-type MS. V-type MS is one of the significant predictors for NAFLD in Japanese women with MS. "
“Aim:  Previous studies have shown significantly elevated levels of interleukin (IL)-6 in cirrhotic patients with minimal hepatic encephalopathy (MHE), but the relationship between circulating levels of IL-6 and ammonia is unclear. The aim of this study is to investigate the relationship between both variables in cirrhotic patients with MHE. Methods:  Psychometric tests including number connection test part A (NCT-A) and digit symbol test (DST) were performed to diagnose MHE in 85 cirrhotic patients. Simultaneously, circulating levels of IL-6 and ammonia were measured. Results:  Thirty-two (37.6%) cirrhotic patients were diagnosed with MHE.