“
“Purpose: The purpose of this meta-analysis was to determine the strength of the association between gynecologic surgeries, tubal ligation and hysterectomy, Blebbistatin order and ovarian cancer.
Methods: We searched the PubMed, Web of Science, and Embase databases for all English-language articles dated between 1969 through March 2011 using the keywords “”ovarian cancer”" and “”tubal ligation”" or “”tubal sterilization”" or “”hysterectomy.”" We identified 30 studies on tubal ligation and 24
studies on hysterectomy that provided relative risks for ovarian cancer and a p-value or 95% confidence interval (CI) to include in the meta-analysis. Summary RRs and 95% CIs were calculated using a random-effects model.
Results: The summary RR for women with vs. without Selleckchem Tozasertib tubal ligation was 0.70 (95%CI: 0.64, 0.75). Similarly, the summary RR for women with vs. without hysterectomy was 0.74 (95%CI: 0.65, 0.84). Simple hysterectomy and hysterectomy with unilateral oophorectomy were associated with a similar decrease in risk (summery RR = 0.62, 95% CI: 0.49- 0.79 and 0.60, 95%CI: 0.47-0.78, respectively). In secondary analyses, the association between
tubal ligation and ovarian cancer risk was stronger for endometrioid tumors (summary RR = 0.45, 95% CI: 0.33, 0.61) compared to serous tumors.
Conclusion: Observational epidemiologic evidence strongly supports that tubal ligation and hysterectomy are associated with a decrease
in the risk of ovarian cancer, by approximately 26-30%. Additional research is needed to determine whether the association between tubal ligation and hysterectomy on ovarian cancer risk differs by individual, surgical, and tumor characteristics.”
“Aim: The aim of this study was to survey early preterm (prior to 32 weeks’ gestation) singleton live births in Iwate Prefecture as a provincial model of the medical situation in Japan.
Materials and Methods: Data from 177 early preterm singleton live births, and 31 445 total live births (January 2005-December 2007) in Iwate Prefecture Japan were used to analyze the incidence of early preterm singleton live birth in each medical service area.
Results: The incidence of spontaneous early preterm singleton find more live birth did not differ between the coastal and inland medical service areas (3.35 vs 3.57 per 1000 live births). In the Morioka medical service area (radius about 40 km), the incidence of spontaneous early preterm singleton live birth in municipalities without obstetric care facilities was significantly higher than that in municipalities with obstetric care facilities (6.62 vs 2.65 per 1000 live births, P < 0.005). The incidence of early preterm singleton live birth due to pregnancy-induced hypertension in the coastal medical service areas was higher than that in the inland areas (1.67 vs 0.71 per 1000 live births, P < 0.05).