CFA results confirmed that anxiety and depressive symptoms are separate constructs and indicative of negative affect. Items with local dependence and DIF were removed resulting in 15 anxiety and 14 depressive symptoms items. The psychometric differences between short forms and simulated computer adaptive tests are presented.
PROMIS pediatric item banks were developed to provide efficient assessment of health-related quality of life domains. This sample provides initial calibrations of anxiety and depressive symptoms item banks and creates PROMIS pediatric instruments, version 1.0.”
“Background and aim: Although the
genetic risk factors for familial and sporadic inflammatory bowel disease (IBD) seem identical, the relative risk for contracting IBD in the familial setting is larger as that seen in the population at large, suggesting this website an important role of epi- and/or c factors in familial IBD. Epidemiological
data indicate a female predominance in IBD, but how this relates to familial IBD has not been assessed.
Methods: Familial IBD patients (N=608) were compared with a cohort of 415 sporadic IBD patients with regards to the patterns of sex and disease type distribution. see more The imprinting pattern in 87 families in which both a parent and a child had IBD was tested using Galton binominal statistics.
Results: The percentage of females in familial IBD population was significantly higher (61%; female/male ratio 1.5) compared with sporadic IBD (54%; female/male ratio 1.2; p=0.011). The analysis of offspring sex distribution pattern revealed significantly higher female to female transmission compared with female to male transmission
rate (36 vs. 18, respectively; p=0.02). A significantly higher number of mother to child transmissions (55 vs. 32 of father to child transmissions) was observed (p=0.018). The female imprinting was specifically related to Crohn’s disease (31 vs. 14 mother vs. father to child transmissions, respectively; p=0.016).
Conclusion: We propose that a female sex-specific epigenetic learn more inheritance pattern for Crohn’s disease is a major contributing factor in the family-specific risk in Crohn’s disease. Sex-specific manifestation of familial Crohn’s disease can partly explain the epidemiologically observed increased relative risk for females for contracting IBD. (C) 2012 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“Background: Patients with Crohn’s disease have an increased frequency of osteopenia and osteoporosis. This randomized, controlled, double-blind study assessed the efficacy of risedronate versus placebo in treating low bone mineral density (BMD) in patients with Crohn’s disease.
Methods: 88 Crohn’s disease outpatients with BMD T-score <-1.0 by dual-energy X-ray absorptiometry were randomly assigned to one of two treatment groups for the two year study duration: one group received risedronate 35 mg weekly while another received placebo.